abstract：:Immunization of mice with synthetic peptide fragments of conservative sites of meningococcal outer membrane proteins led to defense formation against infection with virulent serogroup A and B Meningococci. The role of cellular immunity in the formation of defense against meningococcal infection after immunization with...

journal_title：Bulletin of experimental biology and medicine

authors： Chibiskova OV,Kotel'nikova OV,Nesmeyanov VA,Alliluev AP,Vol'pina OM,Koroev DO,Filatova MP

更新日期：2007-06-01 00:00:00

abstract：:Structural characteristics of the visual cortex area 17 were studied by computer morphometry on autopsied specimens of the brain from children with perinatal injury to the central nervous system and in a group of control children without symptoms of brain injury. In children with perinatal pathology, the thickness of ...

journal_title：Bulletin of experimental biology and medicine

authors： Sal'kov VN,Khudoerkov RM

更新日期：2007-06-01 00:00:00

abstract：:Hepatoprotective activity of pyrimidine derivative hydroxymethyluracil was studied on the model of acute paracetamol-induced liver damage in rats. Hydroxymethyluracil was shown to produce a strong hepatoprotective effect. ...

journal_title：Bulletin of experimental biology and medicine

authors： Mirsaev TR

更新日期：2007-05-01 00:00:00

abstract：:Testosterone and its high-molecular-weight form (testosterone covalently immobilized on bovine serum albumin) induced a rise of intracellular calcium concentration. The effectiveness of dihydrotestosterone was much lower compared to that of testosterone. Gestagens drospirenone and, to a lesser extent, 17alpha-acetoxy-...

journal_title：Bulletin of experimental biology and medicine

authors： Popova NY,Dukhanin AS,Shimanovskii NL

更新日期：2007-05-01 00:00:00

abstract：:The location and activities of nitric oxide synthases in synovial cells during different stages of inflammatory process were studied by the immunocytochemical method in animals with experimental rheumatoid arthritis. Direct involvement of the NOergic mechanisms in the development of adjuvant arthritis was demonstarted...

journal_title：Bulletin of experimental biology and medicine

authors： Belogolovykh LA,Dubikov AI,Medved' EE

更新日期：2007-05-01 00:00:00

abstract：:In some patients with stable and unstable angina pectoris and in some donors without clinical manifestations of cardiovascular diseases and other pathologies, spontaneous platelet aggregation was completely suppressed by glycoprotein IIb-IIIa antagonists blocking the interaction of this glycoprotein with fibrinogen. A...

journal_title：Bulletin of experimental biology and medicine

authors： Sirotkina OV,Zabotina AM,Taraskina AE,Sivachenko EB,Zueva EE,Kadinskaya MI,Buryachkovskaya LI,Uchitel' IA,Khaspekova SG,Vavilova TV,Shvartsman AL,Mazurov AV

更新日期：2007-04-01 00:00:00

abstract：:Enzyme immunoassays showed significantly elevated content of matrix metalloproteinase 7 and type 1 tissue inhibitor of metalloproteinases in tumors compared to adjacent histologically unchanged mucosa of patients with colorectal cancer; the levels of metalloproteinase 9 and type 4 tissue inhibitor of metalloproteinase...

journal_title：Bulletin of experimental biology and medicine

authors： Gershtein ES,Korotkova EA,Shcherbakov AM,Prorokov VV,Golovkov DA,Kushlinskii NE

更新日期：2007-04-01 00:00:00

abstract：:We studied the possibility of reproducing syringomyelia in rabbits by injection of serum from patients with syringomyelia. Clinical signs of syringomyelia and morphological changes in the central nervous system (cavities, dilatation of the cerebrospinal channel, neurodegeneration, gliosis) developed in laboratory anim...

journal_title：Bulletin of experimental biology and medicine

authors： Mirsayev TR,Borisova NA

更新日期：2007-04-01 00:00:00

abstract：:The possibility of using hyaluronidase for the regulation of the state of different pools of mesenchymal precursors in vivo was demonstrated. The reaction of mesenchymal precursor cells depended on the dose of the enzyme. Administration of hyaluronidase in a dose of 20 U/mouse increased the content of stromal precurso...

journal_title：Bulletin of experimental biology and medicine

authors： Goldberg ED,Dygai AM,Zyuz'kov GN,Zhdanov VV,Simanina EV,Gur'yantseva LA

更新日期：2007-04-01 00:00:00

abstract：:Antisense oligonucleotide to alpha2A-adrenoceptors increased the levels of mRNA (reverse polymerase chain reaction) and protein for a key executioner protease of apoptosis caspase-3 (immunoblotting assay) in the cerebral cortex of newborn rats. The relationship between the observed effect and low expression of alpha2-...

journal_title：Bulletin of experimental biology and medicine

authors： Men'shanov PN,Bannova AV,Il'inykh FA,Dygalo NN

更新日期：2007-03-01 00:00:00

abstract：:The concentration of tissue inhibitor of type 1 metalloproteinases in blood serum from intact CBA mice measured by enzyme immunoassay is similar to that in healthy humans. The concentration of tissue inhibitor of type 1 metalloproteinases in mouse bile was higher than in blood serum, while its concentration in liver h...

journal_title：Bulletin of experimental biology and medicine

authors： Korolenko TA,Filatova TG,Savchenko NG,Yuz'ko YV,Goncharova IA,Alexeenko TV

更新日期：2007-03-01 00:00:00

abstract：:Effects of local therapy with miacalcic on the metabolism in articular connective tissue structures under conditions of experimental arthritis are shown. An effect modifying articular tissue metabolism and an antiinflammatory effect preventing the development of inflammatory destructive processes in rabbit articular t...

journal_title：Bulletin of experimental biology and medicine

authors： Belova SV

更新日期：2007-03-01 00:00:00

abstract：:Using an integral qualitative and quantitative approach to the studies of initiation of the biological material crystallogenesis, we showed in experiments with normal human saliva that the external characteristics of biological fluid (pH, osmolality, and environmental temperature) determine the results of crystallizat...

journal_title：Bulletin of experimental biology and medicine

authors： Martusevich AK,Kamakin NF

更新日期：2007-03-01 00:00:00

abstract：:Exposure of rats with experimental diabetes mellitus to wide-band electromagnetic radiation generated by He-Ne laser and modulated by the pancreas and spleen is informing and phenomenological method prolonging animal life span, normalizing blood glucose level, and promoting regeneration of the pancreas. ...

journal_title：Bulletin of experimental biology and medicine

authors： Garyaev PP,Kokaya AA,Mukhina IV,Leonova-Garyaeva EA,Kokaya NG

更新日期：2007-02-01 00:00:00

abstract：:Non-clonal and clonal abnormal cells (hypodiploid, polyploid, and with chromosome aberrations) were detected by the G-method in the bone marrow and blood of the majority of patients with non-Hodgkin lymphomas before therapy. The manifestation of these abnormalities changed individually after treatment. The most incide...

journal_title：Bulletin of experimental biology and medicine

authors： Ankina MA,Zavitaeva TA,Panferova TA,Shakhtarina SV,Pavlov VV

更新日期：2007-02-01 00:00:00

abstract：:Study on a model of 6-day dosed adaptation to heat in rats showed that this adaptation decreased the severity of cardiac arrhythmias during ischemic and reperfusion injury. The duration of arrhythmias decreased not only in the ischemic period, but also under conditions of reperfusion. Adaptation delayed the developmen...

journal_title：Bulletin of experimental biology and medicine

authors： Monastyrskaya EA,Belkina LM,Manukhina EB,Malyshev IY

更新日期：2007-01-01 00:00:00

abstract：:We studied the effects of plant extracts and products of their biological treatment on trans-sialidase activity in human blood plasma. Extracts of kelp, fucus, yarrow, Saint John's wort, onion, and honey in vitro decreased trans-sialidase activity. Extracts of pollen (beebread) and garlic powder produced the maximum i...

journal_title：Bulletin of experimental biology and medicine

authors： Aksenov DV,Kaplun VV,Tertov VV,Sobenin IA,Orekhov AN

更新日期：2007-01-01 00:00:00

abstract：:The incidence of 5 polymorphisms of N-acetyltransferase-2 gene was evaluated in patients with lung cancer. A803G polymorphism is a factor of lung cancer resistance in tobacco smoking Caucasians in Novosibirsk. Opposite effects of NAT2 gene polymorphisms on the risk of lung cancer are possible. ...

journal_title：Bulletin of experimental biology and medicine

authors： Nikishina MV,Vavilin VA,Makarova SI,Lyakhovich VV

更新日期：2007-01-01 00:00:00

abstract：:We compared cytotoxic activity of blood mononuclear leukocytes from healthy donors and lymphokine-activated killer cells generated from them towards tumor and normal cells. Lymphokine-activated killer cells exhibited higher (in comparison with blood mononuclear leukocytes) killer activity towards tumor cells. Lymphoki...

journal_title：Bulletin of experimental biology and medicine

authors： Zhukova OS,Lebedinskaya OV,Shubina IZh,Gerasimova GK,Karamzin AM,Kiselevskii MV

更新日期：2007-01-01 00:00:00

abstract：:Structural characteristics of the adrenal medulla in hypertensive NISAG rats (hereditary stress-induced arterial hypertension) were studied during various periods of postnatal ontogeny. Signs of hyperplasia of the adrenal medulla were most pronounced in adult hypertensive animals with persistent arterial hypertension,...

journal_title：Bulletin of experimental biology and medicine

authors： Buzueva II,Filyushina EE,Shmerling MD,Markel AL,Yakobson GS

更新日期：2006-12-01 00:00:00

abstract：:The development of experimental type II diabetes mellitus in rats was accompanied by dysfunction of inhibitory and stimulatory heterotrimeric G-proteins, components of hormone-sensitive adenylate cyclase signal system. The function of inhibitory G-proteins decreased most significantly under these conditions, which is ...

journal_title：Bulletin of experimental biology and medicine

authors： Shpakov AO,Kuznetsova LA,Plesneva SA,Bondareva VM,Guryanov IA,Vlasov GP,Pertseva MN

更新日期：2006-12-01 00:00:00

abstract：:Potential created by electrogenic ionic pumps under conditions of maximum activation in a warm standard ionic medium with K(+) after preincubation in cold potassium-free solution has two components: a higher ouabaine-insensitive "stationary" component, and a lower "regulatory" component sensitive to ouabaine, furosemi...

journal_title：Bulletin of experimental biology and medicine

authors： Volkov EM,Sabirova AR,Nurullin LF,Zefirov AL

更新日期：2006-12-01 00:00:00

abstract：:The development of MPTP-induced depressive syndrome in rats was accompanied by activation of prolyl endopeptidase and dipeptidyl peptidase IV in the brain frontal cortex. Prolyl endopeptidase activity in the striatum also increased under these conditions. Our results indicate that proline-specific peptidases in the ta...

journal_title：Bulletin of experimental biology and medicine

authors： Krupina NA,Zolotov NN,Bogdanova NG,Orlova IN,Khlebnikova NN,Kryzhanovskii GN

更新日期：2006-11-01 00:00:00

abstract：:Fucoidans isolated from Fucus evanescens and Laminaria cichorioides kelp can inhibit thrombin and factor Xa of the blood coagulation system. In rats, intravenous injection of fucoidans dose-dependently increased anticoagulant activity of the plasma. Fucoidans can form complexes with protamine sulfate. The observed qua...

journal_title：Bulletin of experimental biology and medicine

authors： Drozd NN,Tolstenkov AS,Makarov VA,Kuznetsova TA,Besednova NN,Shevchenko NM,Zvyagintseva TN

更新日期：2006-11-01 00:00:00

abstract：:Pronounced changes in the capillaries, hemodynamic disorders, epitheliocyte degeneration and atrophy develop in the buccal mucosa of patients with types I and II diabetes mellitus in the absence of inflammatory cellular infiltration or with facultative infiltration. The morphogenesis of pathological changes can be reg...

journal_title：Bulletin of experimental biology and medicine

authors： Balakhonov LV,Nepomnyashchikh LM,Aidagulova SV,Bakarev MA,Vlasova LF

更新日期：2006-11-01 00:00:00

abstract：:Analysis of contribution of sympathetic and parasympathetic systems into heart rate variability carried out using atenolol and atropine showed that August rats are characterized by enhanced tone of the sympathetic system and reduced tone of the parasympathetic system compared to Wistar rats. Reduced tone of the parasy...

journal_title：Bulletin of experimental biology and medicine

authors： Kirillina TN,Usacheva MA,Belkina LM

更新日期：2006-10-01 00:00:00

abstract：:Autooxidation of low-density lipoproteins during incubation at 37 degrees C was accompanied by accumulation of LPO products, decrease in UV autofluorescence (FUV), and increase in autofluorescence in the visible band (FVIS). The degree of low-density lipoprotein modification was estimated by calculating the FVIS/FUV r...

journal_title：Bulletin of experimental biology and medicine

authors： Aidyraliev RK,Azizova OA,Vakhrusheva TV,Lopukhin YM,Mirrakhimov MM

更新日期：2006-10-01 00:00:00

abstract：:Lyzed epimastigotes of Trypanosoma cruzi clones P209-1, Gamba1, Sp104-1, MASu, Y7/1, MN12, Cl-Brener, 86/2036, Y7/2-1 inhibit the growth of Ehrlich adenocarcinoma in mice. the tumor decreased 1.5-3 times after 12 daily injections of lysates from 15 million epimastigotes. The protective effect progressed after the inje...

journal_title：Bulletin of experimental biology and medicine

authors： Batmonkh Z,Kallinikova VD,Pakhorukova LV,Kravtsov EG,Karpenko LP,Dalin MV

更新日期：2006-10-01 00:00:00

abstract：:The effect of intravenous transplantation of mesenchymal stem cells on the recovery of cognitive functions was studied in Wistar-Kyoto rats after brain stroke induced by occlusion of the middle cerebral artery in the left hemisphere. Analysis 2 and 5 weeks after stroke showed that transplantation of mesenchymal stem c...

journal_title：Bulletin of experimental biology and medicine

authors： Sokolova IB,Fedotova OR,Zin'kova NN,Kruglyakov PV,Polyntsev DG

更新日期：2006-10-01 00:00:00

abstract：:Metabolic processes in the brain cortex of albino rats with prenatal and postnatal alcohol intoxication were studied by the method of electron paramagnetic resonance. Accumulation of superoxide radical-generating agents, inactivation of superoxide dismutase, and increase in nitric oxide concentration were detected. Ac...

journal_title：Bulletin of experimental biology and medicine

authors： Museridze DP,Sanikidze TV,Svanidze IK

更新日期：2006-09-01 00:00:00

abstract：:Experiments on outbred albino rats showed that single intraperitoneal injection of cytochrome P-450 inhibitor 2-diethylaminoethyl-2,2-diphenylpropylacetate (SKF-525A) in a dose of 50 mg/kg before acute poisoning with 1,2-dichloroethane and trichloroethane in a dose of 1.0 LD(50), metabolized in the body to compounds w...

journal_title：Bulletin of experimental biology and medicine

authors： Zabrodskii PF,Mandych VG,Germanchuk VG

更新日期：2006-09-01 00:00:00

abstract：:Analysis of planned endomyocardial biopsy specimens of heart allotransplants from 22 recipients revealed signs of humoral type rejection (slight, medium, and severe) presenting as fixation of IgG, IgM, and complement components (C3, C4d) in 61 of 63 sections. Permanent presence of rejection signs attests to rheumatoid...

journal_title：Bulletin of experimental biology and medicine

authors： Beletskaya LV,Kupriyanova AG,Kormer AY,Mironkov BL,Kazakov EN,Shumakov VI

更新日期：2006-09-01 00:00:00

abstract：:The rats with neurodegenerative brain disorder induced by administration of a toxic fragment of beta-amyloid demonstrate weakened endothelium-dependent dilation of cerebral vessels, which attested to impaired production of endothelial NO. At the same time, toxic beta-amyloid fragment induced the formation of NO depots...

journal_title：Bulletin of experimental biology and medicine

authors： Mashina SY,Aleksandrin VV,Goryacheva AV,Vlasova MA,Vanin AF,Malyshev IY,Manukhina EB

更新日期：2006-08-01 00:00:00

abstract：:Trekrezan in a dose of 25 mg/kg normalized the lymphocyte immune status and produced an energy-stabilizing effect, which manifested in decreased levels of lactate, ADP, and AMP and increased content of pyruvate and ATP in blood lymphocytes and lung tissue of rats with experimental acute bronchopneumonia. ...

journal_title：Bulletin of experimental biology and medicine

authors： Zarubina IV,Bolekhan AV,Shabanov PD

更新日期：2006-08-01 00:00:00

abstract：:Multivariate analysis was used to examine the morphology of mixed saliva crystals in 55 healthy men and the patients with suspected malignant prostate gland diseases. The established changes in the shape of dendritic crystals in the saliva from prostate-problematic patients were corroborated by the cluster and discrim...

journal_title：Bulletin of experimental biology and medicine

authors： Denisov AB,Pushkar' DY,Denisov SA

更新日期：2006-08-01 00:00:00

abstract：:We studied the effect of melatonin on the relationship between LPO intensity and proteolytic activity in basal nuclei (caudate nucleus, globus pallidus, amygdaloid complex, and nucleus accumbens septi) of rat brain during acute hypobaric hypoxia. Acute hypoxia was accompanied by LPO activation and increase in proteoly...

journal_title：Bulletin of experimental biology and medicine

authors： Sopova IY,Zamorskii II

更新日期：2006-07-01 00:00:00

abstract：:We propose a method of creation of a 3D matrix consisting of native collagen fibers and natural polysaccharide chitosan. The collagen-chitosan hydrogels maintain viability and prolipherative activity of embryonic stem cells obtained from internal cells of mouse blastocyst. The proposed system forming hydrogels in situ...

journal_title：Bulletin of experimental biology and medicine

authors： Selezneva II,Savintseva IV,Vikhlyantseva EF,Davydova GA,Gavrilyuk BK

更新日期：2006-07-01 00:00:00

abstract：:Changes in heart rate and stroke volume after successive blockade of cardiac adreno- and cholinoceptors were examined on rats of different age. It was established that irrespective of animal age the heart rate remained unchanged under conditions of total adreno- and cholinergic blockade of the heart. Stroke volume und...

journal_title：Bulletin of experimental biology and medicine

authors： Abzalov NI,Ziyatdinova AI,Abzalov RR

更新日期：2006-07-01 00:00:00

abstract：:Homocysteine and homocysteic acid increased the stationary level of reactive oxygen species in rat lymphocytes, homocysteic acid being more potent in this respect. The effect of this compound was realized via ionotropic NMDA receptors and group III metabotropic glutamate receptors. Incubation of lymphocytes with homoc...

journal_title：Bulletin of experimental biology and medicine

authors： Vladychenskaya EA,Tyulina OV,Boldyrev AA

更新日期：2006-07-01 00:00:00

abstract：:Burn trauma increased blood chemiluminescence, while lipopolysaccharide in a dose of 1 mg/kg potentiated this effect, activated LPO, and decreased plasma antioxidant activity. In erythrocytes, superoxide dismutase activity increased, while activity of peroxide-utilizing enzymes decreased. Myeloperoxidase content incre...

journal_title：Bulletin of experimental biology and medicine

authors： Mikhal'chik EV,Titkova SM,Anurov MV,Ettinger AP,Korkina LG

更新日期：2006-06-01 00:00:00